Assessment of blood culture and tube agglutination serology test for the diagnosis of typhoid fever amongst malaria-negative patients: a one-year hospital-based study

Salmonella serotypes, including Typhi, S. Paratyphi A, B, and C, are responsible for the systemic, protracted febrile sickness known as typhoid fever. Various antibody-based tests being used diagnosing This study was carried out to assess performance of widal test blood culture diagnosis fever among malaria-negative patients in a tertiary care hospital east Delhi, India. The conducted from July 2021 June 2022 Department Microbiology Delhi. Patients, adult pediatric population, were evaluated participated an observational, prospective on that malaria-negative. Venous samples obtained under strict aseptic conditions further processed serology In our study, prevalence culture-positive species 0.3% (30/10,000 = 0.3%) Among antimicrobial susceptibility patterns, Typhi revealed highest resistance rates Ciprofloxacin (43.33%), Azithromycin (36.66%), third-generation cephalosporins. Out 30 patients, 5 (17%) negative Widal test. samples, all positive, but only 25 show titer above baseline i.e. >1:64. Although is gold standard fever, does play role management especially suspected cases when negative, government hospitals.